Michele Tonelli Selected Research

RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)

1/2018	9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp).
1/2016	Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds.
8/2010	Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase.
3/2010	Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV).

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Michele Tonelli Research Topics

Disease

4	Neoplasms (Cancer) 02/2022 - 01/2013
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 06/2015
3	Diarrhea 01/2018 - 03/2010
2	Glioblastoma (Glioblastoma Multiforme) 02/2022 - 01/2018
2	Respiratory Syncytial Virus Infections 12/2021 - 12/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 11/2016
2	Human Influenza (Influenza) 07/2017 - 01/2016
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2016 - 05/2011
1	Glioma (Gliomas) 02/2022
1	Type 2 Diabetes Mellitus (MODY) 02/2022
1	Neuralgia (Stump Neuralgia) 01/2021
1	Cystic Fibrosis (Mucoviscidosis) 10/2020
1	Infections 01/2018
1	Pestivirus Infections 01/2018
1	Heart Failure 12/2017
1	Neuroinflammatory Diseases 11/2016
1	Brain Diseases (Brain Disorder) 01/2016
1	Malaria 09/2015
1	Vesicular Stomatitis 11/2008

Drug/Important Bio-Agent (IBA)

6	Pharmaceutical PreparationsIBA 10/2021 - 03/2010
4	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2018 - 03/2010
3	Antiviral Agents (Antivirals)IBA 01/2018 - 01/2016
2	BiguanidesIBA 02/2022 - 01/2018
2	rat CLIC1 proteinIBA 02/2022 - 01/2018
2	Metformin (Glucophage)FDA LinkGeneric 02/2022 - 01/2018
2	AnthraquinonesIBA 01/2021 - 01/2021
2	NaphthoquinonesIBA 01/2021 - 01/2021
2	cycloguanilIBA 01/2018 - 07/2017
2	Antimalarials (Antimalarial Agents)IBA 01/2018 - 07/2017
2	benzimidazoleIBA 12/2017 - 01/2013
1	LuteolinIBA 02/2022
1	magnololIBA 02/2022
1	ChloridesIBA 02/2022
1	Proteins (Proteins, Gene)FDA Link 12/2021
1	AminesIBA 10/2021
1	A 7 (A-7)IBA 10/2021
1	Clofazimine (Lamprene)FDA Link 10/2021
1	LigandsIBA 01/2021
1	Biological ProductsIBA 01/2021
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 10/2020
1	moroxydineIBA 01/2018
1	AcridinesIBA 01/2018
1	Proguanil (Paludrine)FDA Link 01/2018
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018
1	Phenformin (Fenformin)IBA 01/2018
1	Oxygen (Dioxygen)IBA 12/2017
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 07/2017
1	Protons (Proton)IBA 07/2017
1	Amantadine (Aman)FDA LinkGeneric 07/2017
1	EnzymesIBA 07/2017
1	LipopolysaccharidesIBA 11/2016
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2016
1	Celecoxib (Celebrex)FDA Link 11/2016
1	Peptides (Polypeptides)IBA 11/2016
1	Prion ProteinsIBA 11/2016
1	Hemagglutinins (Hemagglutinin)IBA 01/2016
1	Neuraminidase (Sialidase)IBA 01/2016
1	PrionsIBA 01/2016
1	Conditioned Culture MediaIBA 01/2016
1	Ion Channels (Ion Channel)IBA 01/2016
1	Chloroquine (Aralen)FDA LinkGeneric 09/2015
1	Amyloid (Amyloid Fibrils)IBA 06/2015
1	Cholinesterases (Cholinesterase)IBA 06/2015
1	BenzimidazolesIBA 01/2013
1	Quinacrine (Mepacrine)IBA 05/2011
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 08/2010
1	poly(tetramethylene succinate-co-tetramethylene adipate)IBA 03/2010
1	2-phenylbenzimidazoleIBA 03/2010
1	ganhuangenin (Sb 1)IBA 11/2008

Therapy/Procedure

2	Therapeutics 12/2021 - 10/2021
1	Precision Medicine 02/2022
1	Traditional Medicine (Folk Remedies) 02/2022